What question did this study set out to answer?

This study aims to compare weight loss outcomes in patients treated with oxandrolone, testosterone, and standard care after significant burn injuries.

April 10, 2026Journal of Burn Care & ResearchOpen Access

C-753-04. Multicenter Analysis of Standard of Care versus Oxandrolone versus Testosterone in Burn Hypermetabolism (MASCOTS)

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This study aims to compare weight loss outcomes in patients treated with oxandrolone, testosterone, and standard care after significant burn injuries.
IRB-approved multicenter retrospective and prospective study.
Patients over 18 with >20% total body surface area thermal burns from 6/2022 to 9/2025.
Exclusion of patients on hormonal therapy and non-thermal injuries.
Primary outcome focused on inpatient weight loss over 5 kg.
Logistic regression used for comparative analysis of weight loss outcomes.
Study included 527 patients: 199 on oxandrolone, 59 on testosterone, and 269 on standard care.
Median hospital stay was longer for hormonal groups compared to standard care.
Inpatient weight loss was significantly different: -4 kg (oxandrolone), -2.4 kg (testosterone), and -0.25 kg (SOC).
No significant difference in the odds of >5 kg weight loss between hormonal groups and SOC.

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Implication

A multicenter analysis compares weight loss outcomes in burn patients treated with anabolic supplements versus standard care, indicating potential treatment strategies.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69d895796c1944d70ce06785 https://doi.org/10.1093/jbcr/irag033.025

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Implication

A multicenter analysis compares weight loss outcomes in burn patients treated with anabolic supplements versus standard care, indicating potential treatment strategies.

C-753-04. Multicenter Analysis of Standard of Care versus Oxandrolone versus Testosterone in Burn Hypermetabolism (MASCOTS)

Key Points

Discussion

Implication

Cite This Study

C-753-04. Multicenter Analysis of Standard of Care versus Oxandrolone versus Testosterone in Burn Hypermetabolism (MASCOTS)

Key Points

Discussion

Implication

Cite This Study

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