A Device for Implementation of the Forced Oscillation Method on Strip Preparations of Biological Tissues in Vitro in Prolonged Experiments

The viscoelasticity of blood vessels determines their biomechanical behavior.The present work aims to develop and validate a new device modification for the forced oscillation method and to elaborate an experimental protocol for investigating the direct effect of opioids on the arterial wall in vitro in a prolonged experiment.The construction and software of a previously constructed device were improved and upgraded.A new photo optic recording system and Analog-To-Discrete conversion and recording scheme were developed.The elaborated experimental protocol allows an accumulative treatment with opioids while keeping the preparation vital.The total error of the measurement modules is less than 4.45%.The device ensures sufficient repeatability and precision in recording the response oscillations and estimating the viscoelastic characteristics of biological tissues.