Synthesis, Characterization, In Silico Studies Of Substituted Azetidinone Bearing Triazole And Thiadiazole Ring, Their Antibacterial Activity”

This study explores the potential of compounds as antibacterial agent by examining its binding interactions with biotin protein ligase and DNA gyrase, essential enzymes in bacterial metabolic pathways. Molecular docking simulations reveal strong affinities between compound 6a and both target proteins. The study also a class of compounds 6(a-e) of substituted azetidinone derivatives of drug. Among of them, Synthesis of novel compound 6(a-e) were showed valuable characteristic and efficacy as antibacterial activity.