Isotretinoin-induced hair growth in a case of hereditary hypotrichosis simplex of the scalp: A promising therapeutic approach

Hereditary hypotrichosis simplex (HHS) is a rare and uncommon genodermatosis characterized by miniaturization of the hair follicle.1 Patients commonly present with concerns regarding insufficient hair length and density. HHS can manifest solely on the scalp or may also involve other areas of body hair. Diagnosis typically relies on the exclusion of other congenital hair and ectodermal disorders.1 Historically, effective treatment options for this condition have been lacking. Despite limited treatment options, recent studies have shown promising outcomes with interventions such as topical, sublingual, and oral minoxidil, topical gentamicin, and platelet-rich plasma injection combined with topical minoxidil 2%.