Tuberculosis (TB) remains one of the commonest infectious diseases in India, where control is difficult due to the emergence of multi-drug-resistant TB (MDR-TB). The rifampicin resistance (RR) is an important surrogate marker of MDR-TB. With increasing use of Xpert MTB/RIF a point of care molecular test for simultaneous detection of TB and resistance to rifampicin, a growing number of rifampicin resistant cases are being detected and notified. Traditional DST, on the other hand, is time-consuming, and there are significant issues with test consistency and drug stability in various culture media. The late detection of medication resistance could be a crucial factor in MDR-TB transmission. As a result, quick diagnostic assays are essential for efficient drug-resistant tuberculosis control. Hence the current study was aimed in determining the rate of rifampicin resistance in sputum smear positive cases by drug susceptibility testing (DST) using Lowenstein Jensen media (Proportion method) and comparing these results with that of CBNAAT results.
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Gowda et al. (2024) studied this question.
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