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July 1, 2024Journal of Medicinal Chemistry

1,3,5-Triaza-7-phosphaadamantane and Cyclohexyl Groups Impart to Di-Iron(I) Complex Aqueous Solubility and Stability, and Prominent Anticancer Activity in Cellular and Animal Models

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Authors

MFMichele De FrancoLBLorenzo BiancalanaCZChiara Zappelli

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Overview

Preclinical study demonstrates potent antitumor efficacy of a di-iron(I) complex in cancer models, indicating strong potential as a stable alternative to cisplatin.

Key Points

  • Potent anticancer activity was achieved by a novel di-iron(I) complex, surpassing cisplatin potency across three human cancer cell lines with marked aqueous stability.
  • FEACYP treatment induced 88% tumor growth suppression on day 15 in murine carcinoma models, matching auranofin efficacy in inhibiting cellular thioredoxin reductase.
  • Multigram-scalable synthesis yielded complexes evaluated in carcinoma spheroids; high cytotoxicity highlights therapeutic promise, though mouse models require validation.

Cite This Study

Franco et al. (2024) studied this question.

synapsesocial.com/papers/68e61ca0b6db6435875aee6ahttps://doi.org/10.1021/acs.jmedchem.4c00641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isocyanide Incorporation Expands the Anticancer Potential of Diiron(I) Aminocarbyne Complexes2026 · 4 citations
  2. 2Ferrocene–Diiron(I) Bis(cyclopentadienyl) Conjugates Exhibit Potent In Vitro Cytotoxicity and Selectivity toward Cancer Cells Associated with ROS Scavenging2026 · 2 citations
  3. 3Diiron(I) Complexes with Promising Anticancer Properties Obtained by CO-To-Isocyanide Substitution of [Fe2Cp2(CO)4]2026
  4. 4Synthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands2024 · 11 citations
  5. 5The Reactivity of Diiron(I) Bis-cyclopentadienyl Tricarbonyl Aminocarbyne Complexes in Aqueous Media: A Case Study for Iron-Based Anticancer Agents2026