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June 13, 2026Inorganic ChemistryOpen Access

The Reactivity of Diiron(I) Bis-cyclopentadienyl Tricarbonyl Aminocarbyne Complexes in Aqueous Media: A Case Study for Iron-Based Anticancer Agents

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Authors

EDEleonora DolcherFSFederico SimonelliFNFatima Nigro

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Overview

Randomized trial shows the reactivity of diiron complexes in aqueous media, indicating potential for anticancer applications.

Key Points

  • This research aims to investigate the reactivity of diiron(I) aminocarbyne complexes in aqueous media and their potential as anticancer agents.
  • Characterization of diiron(I) aminocarbyne complexes using IR, NMR, and XRD.
  • Assessment of degradation in water and DMEM over 72 hours at 37 °C using 1 H NMR and UV–vis.
  • Evaluation of the effects of factors like O2, light, and pH on reactivity through various spectroscopic measurements.
  • The degradation followed zero-order kinetics above mM concentration, with formation of secondary amines and cyclopentadiene.
  • Slowly forming brown precipitates contained iron(III)-oxy(hydroxides) and organic components as confirmed by CHNS analyses, IR, and ESI-MS.
  • The study elucidated the mechanistic pathway leading to disruption of the coordination sphere using DFT.

Cite This Study

Dolcher et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5aefaef96ed7f05797ahttps://doi.org/10.1021/acs.inorgchem.6c01829
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