Advancing Cholesterol Detection: A Simulation Study on SrTiO₃-Based BioFET Biosensors

This study presents an analytical model of a strontium titanate (SrTiO 3 )-based biological field-effect transistor (BioFET) for cholesterol detection. Known for its high dielectric permittivity, surface charge regulation, and superior ionic and thermal conductivity, SrTiO 3 enhances the functionality of biosensors. The BioFET employs a gate functionalized with a cholesterol-specific enzyme, which facilitates potentiometric measurements of cholesterol concentrations. The model establishes a quantitative relationship between cholesterol concentration and gate voltage in enzyme-immobilized SrTiO 3 , demonstrating the high selectivity of SrTiO 3 -based BioFETs for cholesterol detection. This indicates their potential in developing diagnostic tools for cholesterol-related conditions and monitoring food quality. Additionally, the analytical model effectively predicts the behavior of the detection mechanism in electrochemical BioFET biosensors, underscoring its innovative application in fields such as microelectronics, sensors, and catalysis.