Immunization of Mice with AAV-mPTH or AAV-mPTH-GPI-Vector Vaccines Against A Parathyroid Hormone Induced Different T-Cell Proliferation Kinetics of Splenocytes

Parathyroid carcinoma (PC) is a rare neuroendocrine neoplasm characterized by excessive production of parathyroid hormone (PTH). Several reports demonstrated only a partial capability of PTH-targeted vaccination to control tumor progression in PC patients actualizing development of new strategies in PC treatment. The goal of this study was to develop adeno-associated viral (AAV) vector vaccines encoding mouse PTH (mPTH) in the native secreted form (AAV-mPTH) or in a glycosylphosphatidylinositol (GPI) anchored form (AAV-mPTH-GPI), and to investigate the immunogenic potential of both vaccines in laboratory mice.