O-090 Workplace Wellness Solutions Leveraging Digital Therapeutics (Dtx) Resulted in Clinically Meaningful Improvement of Metabolic Parameters in Indian Sedentary Office Workers

Introduction Lifestyle interventions play a primary role in the management of chronic diseases such as Diabetes, Prediabetes and Obesity. Digital Therapeutics can play a crucial role in solving such disorders among the working population, promote well-being, and foster engagement. Methodology In a consumer goods organization, sedentary office workers with diabetes were offered a curated Diabetes and Weight-Loss program. De-identified data of 18(mean age 42.7yrs±6.4; 22%Female) and 40(36.6yrs±5.8;12.5%Female) workers were analyzed who completed diabetes-management and weight-loss program respectively. Both programs provided access to a 90-day curated wellness application, remote-coaching, expert-care, digital-logging (meals, physical activity),and behavioral-therapy. A CGM-device was provided at the start of the Diabetes program. Pre-and post-program anthropometry data (weight-BMI-waist-hip circumferences)were analyzed, and glycemic parameters were assessed. Data were presented as mean and 95%CI, with paired-data being analyzed using Wilcoxon signed-rank test. Results Weight-loss program helped reduce weight/BMI, waist, and hip circumference in 90%,95%,and 85% members respectively. Weight reduction by 2.3(1.6,3.0)kg and BMI by 0.85(0.59,1.11)kg/m2 (p-<0.0001, for both) was evident from a baseline of 79.28(75.43,83.13)kg and 27.63(26.3,28.95)kg/m2 respectively. Waist-and-hip circumferences were reduced by 3.33(2.38,4.28)cm (p-<0.0001) and 1.84(0.75,2.92)cm (p-<0.001) from a baseline of 98.14(94.47,101.8)cm and 103.9(101,106.9)cm respectively. The diabetes-program led to HbA1c reduction by 0.75(0.13,1.37)% (p-0.03) from baseline of 7.17(6.32,8.03)%. 94.4% achieved reduction in weight/BMI. Significant reduction in weight by 3.06(1.69,4.44)kg and BMI by 1.11(0.59,1.63)kg/m2 (p-0.0005, for both) was noted from a baseline of 87.48(79.45,95.51)kg and 30.25(27.74,32.76)(kg/m2) respectively. Waist-and-hip circumferences were reduced in 70.58% and 81.5% respectively. Discussion and conclusion Implementation of Digital-Therapeutics programs showed significant improvements in weight/BMI, waist, hip-circumference, and glycemic control in sedentary office workers.