P-011 Immunome and Occupational Exposome: An Integrated View to Improve Occupational Health in Workplaces Increasingly Impacted by Climate Change

Introduction The immunome is the repertoire of antibodies, T-cell receptors and immune-associated proteins of an individual and its importance is increasingly recognized. The exposome is the combination of all exposures experienced during life by an individual, a subset of which is the occupational exposome. The immune system plays a crucial role in infectious diseases, allergies, autoimmune diseases and cancer development. A wide range of physical, chemical and biological agents may alter the immune response and Climate Change (CC) has an increasingly recognized impact on a number of occupational exposures. Methods Analyzing the existing literature on immunome, occupational exposome, CC and occupational health. Results An increasing complexity arises with regard to the interplay between immune related diseases, CC itself and immune-mediated responses to occupational risk factors whose exposure may increase because of CC (e.g. solar radiation, volatile organic compounds, allergens etc.). Discussion The framework depicted above requires the development and the integration of emerging tools (omics, system biology, big data processing) to be properly analyzed and interpreted in view of implementing preventive and protective measures of workers with multiple and variable exposures in a changing climate. Conclusion Immunome profiling may exert a central role in linking the occupational exposure to workers’ health in a changing climate. The immune response as a whole is involved in a wide range of disease conditions and may provide a reliable, broad and flexible set of biomarkers useful in health surveillance of the exposed workers as well as in contributing to implement the adaptation to CC.