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July 1, 2024

Two new pinophol derivatives from endophytic fungus Penicillium herquei JX4 hosted in Ceriops tagal.

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Authors

XLXian-Lei LaoMWMei‐Zhu WuTZTing Zheng

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Overview

In vitro analysis demonstrates that fungal pinophol derivatives suppress nitric oxide production in mouse macrophage cells, highlighting their potential as anti-inflammatory candidates.

Key Points

  • The newly identified pinophol H suppresses nitric oxide production with an IC50 of 8.12 μmol·L⁻¹, demonstrating potent anti-inflammatory activity.
  • Chromatographic isolation of metabolites from Penicillium herquei JX4 yielded two novel compounds tested against lipopolysaccharide-induced macrophage cells.
  • Findings support the therapeutic value of mangrove endophytes, though tested only in a mouse macrophage cell model requiring further preclinical work.

Cite This Study

Lao et al. (2024) studied this question.

synapsesocial.com/papers/68e62387b6db6435875b5fddhttps://doi.org/10.19540/j.cnki.cjcmm.20240405.202
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