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April 3, 2026Natural Product Research

Studies on secondary metabolites and anti-inflammatory activity of fungus Penicillium citreosulfuratum YFC-1 from Sphagneticola trilobata

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Authors

ZCZhaoxia ChenWLWen-xing LiRCRu-tong Chen

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Overview

Novel compounds from an endophytic fungus exhibit anti-inflammatory effects in macrophages, highlighting potential medicinal uses.

Key Points

  • This research aims to isolate secondary metabolites from the fungus Penicillium citreosulfuratum and evaluate their anti-inflammatory properties.
  • Isolation of compounds from the fungus Penicillium citreosulfuratum YFC-1.
  • Structural elucidation using spectroscopic and quantum chemical methods.
  • Evaluation of anti-inflammatory activity via LPS-induced nitric oxide production in RAW 264.7 macrophages.
  • Isolated a novel alkaloid derivative (microsphaerone H) and a new polyketide (annularin O).
  • Compounds 4, 5, 6, 8, and 13 inhibited nitric oxide production, with IC50 values ranging from 17.99 to 49.88 µM.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5eee5a333a821460db4ehttps://doi.org/10.1080/14786419.2026.2649401
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Two new pinophol derivatives from endophytic fungus Penicillium herquei JX4 hosted in Ceriops tagal].2024
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  3. 3Alkaloids with anti-inflammatory activity from the endophytic fungus <i>Penicillium</i> sp. HZ-52026
  4. 4Polyketide Derivatives from the Macroalga-Associated Fungus <i>Penicillium sclerotiorum</i> Exhibiting Anti-Lymphangiogenic Effect2025
  5. 5Penazaphilones J–L, Three New Hydrophilic Azaphilone Pigments from Penicillium sclerotiorum cib-411 and Their Anti-Inflammatory Activity2023 · 4 citations