Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 5, 2026Natural Product Research

Alkaloids with anti-inflammatory activity from the endophytic fungus Penicillium sp. HZ-5

View Full Paper
Ask AI
Bookmark
Share

Authors

BMBangxun MaoJLJin LiXihua UniversityYZYong ZhangHunan Institute of Science and Technology

Discussion

Loading...

Member takes

Implication

Chemical investigation discovers anti-inflammatory alkaloids in endophytic fungus, indicating potential therapeutic applications.

Key Points

  • This research aims to identify alkaloids from the endophytic fungus Penicillium sp. HZ-5 and evaluate their anti-inflammatory properties.
  • Conducted chemical investigation of ethyl acetate extract from Penicillium sp. HZ-5.
  • Identified four alkaloids through spectroscopic analysis and ECD calculations.
  • Evaluated anti-inflammatory activity by measuring NO production inhibition.
  • Discovered four alkaloids, including two new compounds, penibutanoic A and B.
  • Penibutanoic A and B showed moderate inhibitory effects on NO production with IC50 values of 14.6 µM and 13.9 µM, respectively.

Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/69843412f1d9ada3c1fb1bfehttps://doi.org/10.1080/14786419.2026.2623203
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A new isocoumarin derivative from endophytic fungus Pezicula neosporulosa VDB39 from Vaccinium dunalianum2024 · 4 citations
  2. 2Identification of Novel Target DCTPP1 for Colorectal Cancer Therapy with the Natural Small‐Molecule Inhibitors Regulating Metabolic Reprogramming2024 · 37 citations
  3. 3New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO410152019 · 18 citations
  4. 4Endophytic fungi: hidden treasure chest of antimicrobial metabolites interrelationship of endophytes and metabolites2023 · 142 citations
  5. 5Didymorenloids A and B, two polycyclic cyclopenta[ b ]fluorene-type alkaloids with anti-hepatoma activity from the mangrove endophytic fungus Didymella sp. CYSK-42024 · 18 citations