Study isolates anti-inflammatory compounds from marine-derived fungus, indicating potential for new therapies.
Four new compounds (1–4), along with 22 known metabolites (5–26), were isolated from the fungus Biscogniauxia sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds 1 and 2 were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC50 values of 7.14 and 25.25 μM, respectively.
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Li et al. (2025) studied this question.
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