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November 11, 2025Journal of Natural ProductsOpen Access

Polyketide Derivatives from the Macroalga-Associated Fungus Penicillium sclerotiorum Exhibiting Anti-Lymphangiogenic Effect

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Authors

TKTzu-Yi KeSWShih-Wei WangZLZheng-Yu Lin

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Overview

Research uncovers polyketide derivatives from Penicillium sclerotiorum exhibiting anti-lymphangiogenic properties, suggesting new therapeutic potentials.

Key Points

  • To investigate the anti-lymphangiogenic potential of polyketide derivatives from Penicillium sclerotiorum.
  • Isolated compounds from endophytic fungus Penicillium sclerotiorum
  • Analyzed compounds using ECD, HR-ESI-MS, and NMR spectroscopy
  • Assessed anti-lymphangiogenic activity in vitro with human lymphatic endothelial cells
  • Two polyketide derivatives and other azaphilones were isolated
  • Compounds 4 and 14 demonstrated significant inhibitory activity against lymphatic endothelial cells
  • IC50 values for compounds 4 and 14 were 5.7 ± 0.2 and 5.8 ± 0.2 μg/mL, respectively

Cite This Study

Ke et al. (2025) studied this question.

synapsesocial.com/papers/69252e90c0ce034ddc355fc8https://doi.org/10.1021/acs.jnatprod.5c01132
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on secondary metabolites and anti-inflammatory activity of fungus <i>Penicillium citreosulfuratum</i> YFC-1 from <i>Sphagneticola trilobata</i>2026
  2. 2Penazaphilones J–L, Three New Hydrophilic Azaphilone Pigments from Penicillium sclerotiorum cib-411 and Their Anti-Inflammatory Activity2023 · 4 citations
  3. 3A Novel Lactam and Two Rare Mycophenolic Acid Derivatives from the Fungus Penicillium sclerotiorum JBHL3212024 · 2 citations
  4. 4Generation of Novel Natural Products by Disrupting Azaphilone Synthesis in Penicillum sclerotiorum E23Y-1A2026
  5. 5One New Quinazoline‐Containing Diketopiperazine Isolated from the Marine‐Sponge‐Derived Fungus <i>Penicillium</i> sp. SCSIO410432024 · 1 citations