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The research aims to explore novel natural products by disrupting azaphilone biosynthesis in Penicillium sclerotiorum.

February 28, 2026Marine DrugsOpen Access

Generation of Novel Natural Products by Disrupting Azaphilone Synthesis in Penicillum sclerotiorum E23Y-1A

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Demonstrates new metabolite production in fungi by disrupting azaphilone biosynthesis, indicating potential for natural product discovery.

The research aims to explore novel natural products by disrupting azaphilone biosynthesis in Penicillium sclerotiorum.
Used metabolic shunting strategy to disrupt azaphilone biosynthesis by deleting the regulator gene A00667.
Conducted HPLC analysis to identify metabolite changes in mutant strain Δ667 compared to wild type.
Purified and characterized seven compounds produced by the mutant and wild type strains.
Identified two novel meroterpenoids, sclerotilins A and B, from the mutant strain.
Wild type yielded known compounds including ergosta-5,7,22-trien-3β-ol and cerevisterol.
Compound 6 showed moderate antimicrobial activity against Staphylococcus aureus.
Compound 3 demonstrated moderate cytotoxicity against five human cancer cell lines.

Chang et al. (2026) studied this question.

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Demonstrates new metabolite production in fungi by disrupting azaphilone biosynthesis, indicating potential for natural product discovery.