This study presents a case series of Giant Cell Tumor of Tendon Sheath (GCTTS) from Vydehi Institute of Medical Sciences and Research Centre, Bangalore. Four cases were surgically treated and followed up for three months to one year, revealing no recurrence. GCTTS, though benign, commonly recurs post-surgery. Proper excision and regular follow-up are vital for effective management. Various diagnostic modalities and differential diagnoses are discussed, emphasizing the importance of complete excision to prevent recurrence. The study contributes to understanding GCTTS's clinical presentation, diagnosis, and management, providing valuable insights for orthopedic practice. Giant cell tumor of the tendon sheath (GCTTS) is a benign soft tis Introduction: sue lesion commonly found in the exor aspect of the hand and wrist. Despite surgical removal, the tumor often recurs. This study reviews four cases treated with excision and followed for three months to one year. This observational study examines four cases of GCTTS treated Materials and Methods: surgically. Postoperative monitoring lasted from three months to one year. Observations: None of the cases in our series experienced recurrence during the follow-up period, which contrasts with literature reporting recurrence rates of 10-40%. Conclusion: Regular follow-up care and complete excision are crucial for GCTTS due to its high recurrence rate. Recurrence is primarily inuenced by incomplete excision and residual satellite nodules.
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