A Prospective Randomized Control Study on Magneseum Sulfate Versus Ketamine Nebulization on the Efficacy in the in Prevention of Incidence of Postoperative Sore Throat

Background: Anaesthesia's main purpose is to control the airways, and endotracheal intubation, an essential part of the procedure. After extubation, ET (endotracheal tubes) may cause local irritation and inammation, which can lead to the development of Post Operative Sore Throat (POST). Material And Methods: Total 102 patients of ASA Grade 1, Grade 2 were randomized into two groups of 51 each, Group K received nebulization with 50 mg ketamine (1 ml with 2 ml of normal saline) and Group M were nebulized with 3ml of 225 mg isotonic magnesium sulfate. Patients were nebulized 10 minutes prior to induction. Statistical analysis was conducted using SPSS Version 21.0, with signicance dened as P< 0.05. Results: Current results show that, the age, sex and hemodynamic changes did not signicantly differ between the two groups. The magnesium sulfate group had 43.1% Post Operative Sore Throat (POST) incidence while the ketamine group had 9.8% incidence. Conclusion: In the current study, it was found that the magnesium sulphate group experienced a higher incidence of Post Operative Sore Throat (POST) compared to the ketamine group. Hemodynamic variables, the time required for rescue analgesia, and adverse reactions were not signicantly different. Thus, Ketamine nebulization should be preferred over MgSO4 nebulization in the prevention of development of POST.