Understanding the Correlation Between Apolipoprotein B and LDL Cholesterol

Background: Elevated levels of apolipoprotein B lipoproteins increase the risk of cardiovascular disease (CVD). This study aimed to understand the correlation between apolipoprotein B and low-density lipoprotein cholesterol (LDL-C). Methods: This cross-sectional observational study was conducted among conference attendees including healthcare professionals and pharma professionals. All study participants were requested to provide written informed consent for the collection and analysis of their clinical data, including blood samples for lipid prole check-ups. Data related to age and sex were gathered from the participants, and blood samples were collected immediately after an event. Results: A total of 69 participants were included, with a mean age of 44.4 years, and 89.9% were male. The mean levels of apolipoprotein B, high-density lipoprotein cholesterol (HDL-C), and LDL-C were 94.5 mg/dL, 41.3 mg/dL, and 109.4 mg/dL, respectively. The mean apolipoprotein B and LDL-C were signicantly higher in participants aged between 36 and 50 years compared to ≤35 years and >50 years (P=0.025 and P=0.005, respectively). The mean LDL-C was signicantly higher in participants with apolipoprotein B levels≥130 mg/dL compared to <130 mg/dL (P=0.001). Apolipoprotein B was positively correlated with cholesterol/HDL-C ratio (r=0.784; P<0.001), LDL-C (r=0.914; P<0.001), LDL-C/HDL-C ratio (r=0.779; P<0.001), non-HDL-C (r=0.973; P<0.001) and total cholesterol (r=0.945; P<0.001). Conclusion: The association between high apolipoprotein B levels and LDL-C, indicates a potential risk factor for CVD among study participants. This emphasizes the necessity of monitoring and managing apolipoprotein B levels to reduce the risk of CVD in clinical settings