Epidemiological analysis reveals complex correlations between apolipoproteins and cholesterol fractions in cardiovascular risk assessment, highlighting the need to clarify their interdependence.
Plasma levels of apolipoprotein B (apoB), the main surface protein on LDL particles, and LDL-C, the amount of cholesterol in those particles, are closely correlated and, considered separately, are positive risk factors. Plasma levels of apolipoprotein A 1 , the main surface protein on HDL particles, and HDL-C, the amount of cholesterol in those particles, are also closely correlated with each other and, considered separately, are negative risk factors. The interdependence of these four risk factors is unclear.
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Mouquet et al. (2011) studied this question.
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