546 Effects of Different Weight Loss Programs on Oncological Outcomes Following Curative Resection of Digestive Tract Cancers

Aim The review aimed to investigate the impact of weight loss programs on the long-term oncological outcomes of overweight and obese patients following curative gastrointestinal (GI) cancer resections. Given the association between obesity and heightened risks in cancer patients, the study sought to assess the effectiveness of various weight loss interventions, including lifestyle modifications, pharmacological agents, bariatric surgery, or their combinations. Method A comprehensive search strategy utilising MeSH and free-text terms was employed across multiple electronic databases, without language or publication status restrictions. Inclusion criteria focused on randomised controlled trials involving any type of weight loss intervention for overweight or obese patients following curative GI cancer resection. The GRADE approach was intended for risk of bias assessment and primary outcomes encompassed overall mortality, local recurrence, and distant recurrence. Secondary outcomes included quality of life, disease-free survival, overall complication rate and time to recurrence. Results Despite the systematic search, no randomized controlled trials meeting the specified inclusion criteria were identified. As a result, the review lacked empirical data to draw conclusions regarding the outcomes of weight loss programs in this patient population following curative GI cancer resection. Conclusions The absence of conclusive evidence highlights a critical gap in understanding the impact of weight loss interventions on the oncological outcomes of overweight and obese patients after GI cancer resections. Given the increasing survival rates post-resection with advanced surgical treatments, there is a pressing need to comprehend the potential influence of weight loss programs on recurrence. Large multicentre randomised controlled trials are required to assess these outcomes.