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December 19, 2025Annals of Gastroenterological SurgeryOpen Access

Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study

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Why the study?

Surgeries for colorectal cancer in obese patients are increasingly common and obesity may complicate procedures and impair oncology, but its true clinical impact remains unclear.

Does obesity worsen perioperative and oncological outcomes in patients undergoing surgical resection for colorectal cancer?

Population

2905 patients with stage I–IV CRC undergoing surgical resection

Comparison

Non-obesity (BMI < 25 kg/m2) vs mild-obesity (BMI 25 to < 30 kg/m2) vs severe-obesity (BMI ≥ 30 kg/m2)

Design

Prefecture-wide multicenter retrospective study

Authors

KTKazuhiro TaguchiMSManabu ShimomuraWSWataru Shimizu

Discussion

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Overview

Obesity may impair lymph node staging accuracy in colorectal cancer; leaves open its independent prognostic impact in stage III.

Structured PICO

Does obesity worsen perioperative and oncological outcomes in patients undergoing surgical resection for colorectal cancer?

P
Population
2905 patients with stage I-IV colorectal cancer who underwent surgical resection between 2017 and 2019, categorized by BMI into non-obesity (n=2283), mild-obesity (n=576), and severe-obesity (n=91).
I
Intervention
Surgical resection in obese patients (BMI ≥ 25 kg/m2)
C
Comparator
Surgical resection in non-obese patients (BMI < 25 kg/m2)
O
Outcome
Perioperative outcomes, long-term survival (recurrence-free survival and overall survival), and lymph node metrics (including log odds of positive lymph nodes [LODDS])hard clinical

Obesity increases surgical complexity and impairs pathological lymph node evaluation in colorectal cancer surgery, potentially contributing to poorer prognosis in stage III patients.

Cite This Study

Taguchi et al. (2025) studied this question.

synapsesocial.com/papers/6a87b04f02f504243ce954echttps://doi.org/10.1002/ags3.70156
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of Obesity on Operative Outcomes and Long-Term Oncological Outcomes Following Rectal Cancer Surgery: A Retrospective Single-Center Study2026
  2. 2Path Analysis of the Impact of Obesity on Postoperative Outcomes in Colorectal Cancer Patients: A Population-Based Study2021 · 9 citations
  3. 3Obesity Selectively Increases Intraoperative Risk in Left-Sided Colon Cancer Surgery: A Retrospective Cohort Study2025
  4. 4The Impact of Obesity on Perioperative Outcomes After Laparoscopic Colorectal Resection2011 · 169 citations
  5. 5Obesity and overweight are associated with worse survival in early-onset colorectal cancer2024 · 15 citations