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June 29, 2021Journal of Clinical MedicineOpen Access

Path Analysis of the Impact of Obesity on Postoperative Outcomes in Colorectal Cancer Patients: A Population-Based Study

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Key result

Obesity in patients undergoing colorectal cancer surgery was associated with increased incidence of postoperative infection by 1.9%, as well as increased in-hospital mortality and length of stay.

Why the study?

Obesity adversely affects perioperative outcomes, but long-term outcomes do not appear affected by excess body weight, prompting examination of obesity and surgical outcomes in colorectal cancer.

Does obesity increase postoperative complications and in-hospital mortality in patients with colorectal cancer undergoing surgery?

Population

107,067 patients aged 20 years or older diagnosed with colorectal cancer who underwent surgery

Comparison

Obese patients vs matched non-obese controls

Design

Population-based matched retrospective database study

Authors

KCKuan‐Chih ChungChang Gung UniversityKLKo‐Chao LeeKaohsiung Chang Gung Memorial HospitalHCHong‐Hwa ChenChang Gung University

Discussion

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Member takes

Overview

Obesity is associated with increased postoperative complications, in-hospital mortality, length of stay, and hospital charges in patients undergoing surgery for colorectal cancer.

Study Design

Type

Cohort (n=107,067)

Multicenter

Yes

Structured PICO

Does obesity increase postoperative complications and in-hospital mortality in patients with colorectal cancer undergoing surgery?

P
Population
107,067 patients aged ≥20 years with colorectal cancer undergoing surgery, identified from the US National Inpatient Sample database.
E
Exposure
Obesity (ICD-9-CM code: 278.0)
C
Comparator
Non-obese controls matched in a 1:4 ratio for age, sex, and severity of CRC (metastasis vs. no metastasis)
O
Outcome
Postoperative complications (infection, shock, bleeding, wound disruption, digestive system complications), in-hospital mortality, length of hospital stay, and total hospital chargeshard clinical

Main Result

Effect estimate: 1.9% increase

Obesity is associated with increased postoperative complications, in-hospital mortality, length of stay, and hospital charges in patients undergoing surgery for colorectal cancer.

Cite This Study

Chung et al. (2021) conducted a cohort in Colorectal cancer (n=107,067). Obesity vs. Non-obese was evaluated on postoperative infection (1.9% increase). Obesity in patients undergoing colorectal cancer surgery was associated with increased incidence of postoperative infection by 1.9%, as well as increased in-hospital mortality and length of stay.

synapsesocial.com/papers/6a7f3749dac4de2d60b3adc8https://doi.org/10.3390/jcm10132904
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity – a risk factor for postoperative complications in general surgery?2015 · 326 citations
  2. 2Global patterns and trends in colorectal cancer incidence and mortality2016 · 5,418 citations