Differential Diagnosis of Cytomegalovirus Infection and Disease in HIV/AIDS Patients: A Six-Year Retrospective Analysis

Objective: It is difficult to distinguish cytomegalovirus (CMV) infection and disease since CMV is a latent virus and can cause recurrent infections. Positive CMV tests may not necessarily be indicative of active disease. There is no clear threshold value for plasma CMV-DNA polymerase chain reaction (PCR) levels to distinguish disease from viral reactivation. In this study, we aimed to determine a numerical value to identify CMV-related clinical syndromes and to differentiate between CMV infection and disease in HIV/AIDS patients.