Key result
Quantitative CMV PCR ≥500 copies correlates with clinical symptoms and antiviral response in transplant recipients.
Why the study?
Does quantitative CMV PCR testing correlate with clinical symptoms and response to antiviral therapy in cardiac and renal allograft recipients?
Population
120 allograft recipients (95 cardiac and 25 renal)
Comparison
Qualitative and quantitative polymerase chain… vs Blood buffy coat culture and anti-CMV antibody…
Design
Cohort
Follow-up
up to 3 years
Authors
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May support CMV PCR monitoring in allograft recipients; leaves open need for randomized confirmation.
Observational (n=120)
Does quantitative CMV PCR testing correlate with clinical symptoms and response to antiviral therapy in cardiac and renal allograft recipients?
Quantitative CMV PCR is a sensitive and reliable method for early detection of CMV infection and monitoring response to antiviral therapy in transplant recipients.
Toyoda et al. (1997) conducted an observational in Cytomegalovirus (CMV) infection in allograft recipients (n=120). Quantitative CMV PCR vs. Blood buffy coat culture and anti-CMV antibody IgM assays was evaluated on Detection of CMV infection and correlation with clinical symptoms and antiviral therapy response. Quantitative CMV PCR detected CMV infection in 26 of 120 transplant recipients, with DNA levels ≥500 copies correlating with clinical symptoms and distinguishing responders to antiviral therapy.
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