Synthesis, Antioxidant and Cytotoxic Activity Studies of 2-Chlorobenzo[h]quinoline containing 2,4,5-Trisubstituted Imidazole Derivatives

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A series of 2-chlorobenzo[h]quinoline containing 2,4,5-trisubstituted imidazole derivatives (4a-h) were synthesized and characterized by 1H NMR, 13C NMR, FT-IR and mass spectral analysis. All the synthesized compounds were evaluated for their in vitro antioxidant activity by DPPH method and cytotoxicity study against Colo-205, HeLa and A549 human cancer cell lines by MTT assay method. Among the synthesized compounds, compound 4a has showed significant cytotoxicity against all the three tested cancer cell lines, compound 4f showed good cytotoxic activity against Colo-205 and HeLa cell lines, while compound 4c has showed good cytotoxicity against HeLa cell line. With respect to antioxidant activity, the synthesized compounds 4a, 4d and 4e found to exhibit good activity as compared to other compounds of the series.