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April 1, 2026Russian Journal of Organic Chemistry

Synthesis and Evaluation of 1,2,3-Triazole-Linked Trifluoromethyl Quinazolinone Derivatives as Anticancer Agents: Docking Interaction Analysis

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Authors

MJMohammad JunaidVignan's Foundation for Science, Technology & ResearchSGSanthosh Kumar GauthamNational Institute of Malaria ResearchSGShravan Kumar GundaOsmania University

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Overview

Novel triazole-linked quinazolinone compounds show anticancer activity in human cancer cell lines, suggesting a potential therapeutic approach.

Key Points

  • This research aims to synthesize and evaluate new triazole-linked trifluoromethyl quinazolinone derivatives for their anticancer properties.
  • Synthesis of triazole-linked derivatives through multi-step reactions starting from 2-amino-6-(trifluoromethyl)benzonitrile.
  • Utilization of copper-catalyzed azide-alkyne cycloaddition to form the target compounds.
  • Evaluation of the anticancer activity of final compounds against four human cancer cell lines.
  • Compounds with 4-(ortho-hydroxyphenyl) and 4-(ortho-fluorophenyl) substituents showed significant anticancer activity.
  • Docking interaction analysis for these compounds indicated promising binding properties.

Cite This Study

Junaid et al. (2026) studied this question.

synapsesocial.com/papers/69cd79bb5652765b073a69a1https://doi.org/10.1134/s1070428025603589
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