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April 21, 2026Letters in Organic Chemistry

Synthesis and Docking of Triazole, Pyrazole, and Schiff Base LinkedQuinazolinones for Anticancer and Antimicrobial Applications

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Authors

MJMohammad JunaidSGSanthosh Kumar GauthamSBSrinu Bhoomandla

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Overview

Novel quinazolinone derivatives demonstrate anticancer and antibacterial properties, suggesting potential therapeutic applications.

Key Points

  • The aim is to synthesize novel quinazolinone derivatives and evaluate their anticancer and antimicrobial properties.
  • Synthesis of quinazolinone derivatives using various chemical reactions.
  • Evaluation of anticancer activity against multiple human cancer cell lines and normal cells.
  • Screening of antimicrobial activity against bacterial strains and Candida using well diffusion method.
  • Certain quinazolinone derivatives showed significant anticancer activity against HeLa, COLO 205, HepG2, and MCF7 cell lines.
  • Some compounds exhibited promising antibacterial effects against both Gram-positive and Gram-negative bacteria and Candida strains.

Cite This Study

Junaid et al. (2026) studied this question.

synapsesocial.com/papers/69e713b4cb99343efc98d359https://doi.org/10.2174/0115701786430284251214170953
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis and Evaluation of 1,2,3-Triazole-Linked Trifluoromethyl Quinazolinone Derivatives as Anticancer Agents: Docking Interaction Analysis2026
  2. 2Synthesis, Characterization, Biological Activity And Molecular Docking Studies Of 1,2,4-Triazole Linked Quinoline Derivatives2025
  3. 3Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents2026
  4. 4Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-d] pyrimidines2024 · 57 citations
  5. 5Molecular docking, synthesis, and cytotoxic evaluation of novel quinazoline-quinazolinone hybrid compounds2026