June 26, 2024Blood AdvancesOpen Access

CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation

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Authors

DZDanniel ZamoraCity Of Hope National Medical Center HXHu XieChina Three Gorges University ASAlicja Sadowska‐KlasaCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa

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Implication

Cohort study demonstrates pre-transplant cytomegalovirus reactivation increases post-transplant infection risk in transplant candidates, highlighting routine surveillance to guide therapy.

Key Points

Cytomegalovirus reactivation before hematopoietic cell transplantation significantly increases post-transplant viral disease, reactivation, and one-year mortality.
Pre-transplant reactivation occurred in 11% of candidates at a median of 14 days before graft infusion, while severe lymphopenia was the strongest predictor.
Assessment using routine polymerase chain reaction surveillance highlights that viral clearance before transplantation significantly lowers post-HCT reactivation risk.

Cite This Study

Zamora et al. (2024) studied this question.

synapsesocial.com/papers/68e6328ab6db6435875c44d7 https://doi.org/10.1182/bloodadvances.2023012234

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Implication

Cohort study demonstrates pre-transplant cytomegalovirus reactivation increases post-transplant infection risk in transplant candidates, highlighting routine surveillance to guide therapy.

CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation

Discussion

Member takes

Implication

Key Points

Cite This Study

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