Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Yu Amanda Guo; Tanmay Kulshrestha; Mei Mei Chang; Irfahan Kassam; Egor Revkov; Simone Rizzetto; Aaron C. Tan; Daniel S.W. Tan; Iain Beehuat Tan; Anders J. Skanderup

doi:10.1158/2767-9764.26106958.v1

June 26, 2024Open Access

Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

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Key Points

Transcriptome deconvolution shows differentially enriched immune cell types between responders and non-responders to immune checkpoint blockade.
Expression signature profiles demonstrate distinct cellular abundance patterns, while cancer cell expression signatures remain largely absent.
Highlights the dominant role of diverse immune cell types during immune checkpoint blockade response, guiding future biomarker exploration.

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Implication

Transcriptome deconvolution reveals differential enrichment of immune cell types across treatment response groups, highlighting immune composition shifts.

Abstract

Differentially enriched immune cell types between responders and non-responders.

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Cite This Study

Guo et al. (2024) studied this question.

synapsesocial.com/papers/68e633b3b6db6435875c5911 https://doi.org/10.1158/2767-9764.26106958.v1

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Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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