Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Yu Amanda Guo; Tanmay Kulshrestha; Mei Mei Chang; Irfahan Kassam; Egor Revkov; Simone Rizzetto; Aaron C. Tan; Daniel S.W. Tan; Iain Beehuat Tan; Anders J. Skanderup

doi:10.1158/2767-9764.26106958

June 26, 2024Open Access

Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

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Key Points

Differentially enriched immune cell types distinguish responders from non-responders during immune checkpoint blockade therapy across patient cohorts.
Transcriptome deconvolution profiles specific immune cell populations, tracking differential enrichment patterns between treatment response groups.
Absence of cancer cell expression signatures indicates that immune cell types within the microenvironment may primarily govern checkpoint blockade outcomes.

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Implication

Transcriptome deconvolution reveals differentially enriched immune cell types in checkpoint blockade responders, indicating immune microenvironment roles.

Abstract

Differentially enriched immune cell types between responders and non-responders.

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Cite This Study

Guo et al. (2024) studied this question.

synapsesocial.com/papers/68e633b3b6db6435875c5988 https://doi.org/10.1158/2767-9764.26106958

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Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 6 from Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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