Quantitative Comparison of Ventilation Parameters of Different Approaches to Ventilator Splitting and Multiplexing

CONTEXT: Amid the COVID-19 pandemic, this study delves into ventilator shortages, exploring simple split ventilation (SSV), simple differential ventilation (SDV), and differential multiventilation (DMV). The knowledge gap centers on understanding their performance and safety implications. HYPOTHESIS: Our hypothesis posits that SSV, SDV, and DMV offer solutions to the ventilator crisis. Rigorous testing was anticipated to unveil advantages and limitations, aiding the development of effective ventilation approaches. METHODS AND MODELS: Using a specialized test bed, SSV, SDV, and DMV were compared. Simulated lungs in a controlled setting facilitated measurements with sensors. Statistical analysis honed in on parameters like peak inspiratory pressure (PIP) and positive end-expiratory pressure. RESULTS: Setting target PIP at 15 cm H 2 O for lung 1 and 12.5 cm H 2 O for lung 2, SSV revealed a PIP of 15.67 ± 0.2 cm H 2 O for both lungs, with tidal volume (V t ) at 152.9 ± 9 mL. In SDV, lung 1 had a PIP of 25.69 ± 0.2 cm H 2 O, lung 2 at 24.73 ± 0.2 cm H 2 O, and V t s of 464.3 ± 0.9 mL and 453.1 ± 10 mL, respectively. DMV trials showed lung 1’s PIP at 13.97 ± 0.06 cm H 2 O, lung 2 at 12.30 ± 0.04 cm H 2 O, with V t s of 125.8 ± 0.004 mL and 104.4 ± 0.003 mL, respectively. INTERPRETATION AND CONCLUSIONS: This study enriches understanding of ventilator sharing strategy, emphasizing the need for careful selection. DMV, offering individualization while maintaining circuit continuity, stands out. Findings lay the foundation for robust multiplexing strategies, enhancing ventilator management in crises.