Formulation Development and Evaluation of Effervescent Granules of Rizatriptan Benzoate

The present study describes the formulation and development of rizatriptan benzoate (RZB) effervescent granules and compares its dissolution rate against the conventional rizatriptan benzoate tablets. Earlier, placebo-effervescent granules were prepared to optimize the concentration of citric acid, NaHCO3 and tartaric acid and its effect on CO2 content and effervescence time. Effervescent granules were prepared by direct sifting and blending of ingredients. Rizatriptan effervescent granules were prepared by the addition of RZB in the above-optimized placebo granule formula and evaluated for various physicochemical parameters. Later, the effervescent RZB granules were compared with the marketed RZB tablets for the dissolution rate. It was observed that RZB effervescent granules have the fastest dissolution rate compared with marketed RZB tablets. The optimized RZB effervescent granule formulation is quite superior to that of RZB conventional tablets to relieve the patients from migraine and the possible associated hyperacidity it.