The Homocysteine Level in Young Patients With Arterial Hypertension Homozygous for the Pathological Allele in the Candidate Genes Agtr1 1166 A>c and Nos3 894 G>t

Background. In recent years, polymorphisms in candidate genes have played a major role in the study of the pathogenesis of arterial hypertension (AH) and other cardiovascular diseases (CVD). However, the authors of several studies have drawn attention to the association of point mutations in candidate genes associated with AH with independent predictors of cardiovascular complications as homocysteine. This article presents the results of the analysis of homocystein concentration in young patients with hypertension homozygous for the pathological allele in the candidate genes AGTR1 1166 and NOS3 894. Purpose. To analyze the homocysteine concentration in young patients with AH homozygous for the pathological allele in candidate genes AGTR1 1166 and NOS3 894. Materials and Methods. The study included 89 patients diagnosed with hypertension of young age (the average age was 33.2±2.79). Polymorphism in the AGTR1 1166 A>C and NOS3 894 G>T genes was analysed, as well as concentration determination by traditional PCR, and homocysteine concentration by enzyme immunoassay. Results. Statistically significant differences in serum homocysteine concentrations were obtained between the general group of patients with hypertension and the group of patients with hypertension homozygous for the pathological allele (TT) in the NOS3 894 G>T gene. Conclusion. In the group of young patients with hypertension homozygous for the pathological allele (TT) in the NOS3 894 G>T gene, the level of homocysteine in the blood serum was significantly higher compared with patients with the "wild" allele (GG) and the heterozygous allele (GT).