Key result
The presence of the T allele of the G894T NOS3 polymorphism in overweight patients with hypertension was associated with significantly lower systolic blood pressure (122.6 vs 132.3 mmHg).
Why the study?
The study was conducted to establish the prevalence of the G894T polymorphism of the NOS3 gene among patients with primary arterial hypertension with overweight and its effect on the course of the disease.
Does the G894T polymorphism of the NOS3 gene affect the age of onset and blood pressure control in patients with primary arterial hypertension and overweight?
Observational (n=58)
No
Does the G894T polymorphism of the NOS3 gene affect the age of onset and blood pressure control in patients with primary arterial hypertension and overweight?
Absolute Event Rate: 122.6% vs 132.3%
p-value: p=<0.05
The G894T polymorphism of the NOS3 gene is associated with the age of onset and the degree of blood pressure control in overweight patients with primary arterial hypertension.
Hypothesis-generating for NOS3 G894T in overweight hypertension; does not support practice change without prospective validation.
The objective: to establish the prevalence of the G894T polymorphism of the NOS3 gene among patients with primary arterial hypertension (AH) with overweight and its effect on the course of the disease.Material and methods. 58 patients with AH and body mass index (BMI) of <25 kg/m2 were examined: 22 (38%) men and 38 (62%) women; middle-aged: 53,6±8,7 years. 3 (5%) patients had impaired carbohydrate tolerance, 10 (17%) had type 2 diabetes. 48 patients with hypertension stage I, 5 – stage II and 5 – stage III.Results. The «wild» homozygous genotype GG was detected in 35 (60,3%) patients, the heterozygous genotype GT – in 20 (34.5%) and the «mutant» homozygous TT genotype – in 3 (5,2%) patients. Allele G has 94,8% of those surveyed, allele T – 39,7% of patients. The debut of hypertension on average in patients with the homozygous TT genotype at 38,7 years old, in patients with the GT genotype at 47,5 years old and in patients with the homozygous GG genotype at 43,6 years old. The presence of the T allele in patients with AH with overweight is associated with a significantly lower average level of mean daily systolic and diastolic blood pressure (122,6±22,1 mm Hg vs 132,3±16,5 mm Hg vs; р<0,05 and 76,5±8,1 mm Hg vs. 84,5±16,5 mm Hg vs; р<0,05).Conclusion. The majority (60,3%) of patients with AH and overweight had GG genotype of the G894T NOS3 polymorphism, 34,5% and 5,2% respectively had GT and TT genotypes, while among healthy individuals there were 28,9%, 67,5% and 3,6%. Patients with the GT genotype fell ill with AH 4,5 years earlier than patients with the GG genotype (5,7±4,2 years vs. 10,2±6,0 years; р<0,005). The presence of the T allele of this gene in patients receiving antihypertensive therapy is associated with better control of systolic and diastolic blood pressure than in patients of the comparison group (122,6±22,1 mm Hg vs., 132,3±16,5 mm Hg vs.; р<0,05 and 76,5±8,1 mm Hg vs, 84,5±16,5 mm Hg vs; р<0,05).
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Potaskalova et al. (2019) conducted an observational in Primary arterial hypertension and overweight (n=58). T allele of G894T NOS3 polymorphism vs. Absence of T allele (GG genotype) was evaluated on Mean daily systolic blood pressure (p=<0.05). The presence of the T allele of the G894T NOS3 polymorphism in overweight patients with hypertension was associated with significantly lower systolic blood pressure (122.6 vs 132.3 mmHg).
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