Synthesis, Pharmacological Study of 3,5-Di- Substituted Isoxazole Derivatives as Anticancer Drug Against Breast Cancer Cell Line Followed by Computational Study

Objective: Cancer has remained a challenge to the healthcare system due to changes in eating habits and lifestyle, tremendous side effects of chemotherapy, and resistance to existing treatment due to mutations, which creates difficulty in identifying specific targets. Chemistry and Methodology: In this study, equimolecular amounts of reagents were used to synthesize substituted isoxazoles from alpha-beta unsaturated intermediates. Result: Compounds were collected in varying amounts of yield. Spectroscopic data supports the formation of compounds. Compound Id shows GI50 of 46.3 μg/mL against MDA-MB-231. Conclusion: The effective synthesis of novel derivatives has opened up exciting new avenues for medicinal research; one of these compounds has moderate anticancer properties.