DNA hypomethylation of the TERT locus in neuroblastoma cell lines, tumors and O-PDX. A, Alignments of DNA methylation from WGBS for the TERT locus in neuroblastoma cell lines (black), autopsy (red), and O-PDX (blue). Tumor autopsies and O-PDX that are derived from the same patients are connected by a curved line. The hypomethylated region shaded in gray starts −694 bases from the TERT TSS and ends 758 bases after the TSS.
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Graham et al. (2024) studied this question.
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