PHYSIOLOGICAL CHANGES PRODUCED BY THE BETA ADRENERGIC AGONIST-CLEMBUTEROL-β2AA-CLB, IN BOVINE

Nowadays, there are several latent problems worldwide linked to food production: 1-the increase in world population, 2-the increase in war conflicts, the latter linked to the distribution of raw materials for food production, and finally 3-global climate changes, however, biotechnological processes for food production influence the increase in the production of synthetic foods and the use of food additives in animals, their products and by-products are consumed by man, All this in order to increase foods with high nutritional and energy value, which do not nourish, bringing with them an increase in diseases to the animal itself and to man, for this this research has been developed, carried out for more than 15 years of work, which today shows that the use of feed additives is increasing in many livestock regions, mainly in feed a synthetic component called Beta-adrenergic agonist (β2AA), such as clenbuterol-Clb.This is considered a powerful broncho-vessel-dilator, used to control respiratory diseases in horses and humans mainly; Clb is a β2-adrenergic agonist (β2-AA), which causes an increase in muscle mass in birds, cattle, goats and sheep.On the other hand, the metabolic pathways on the effect of Clb are not known to date.They are well elucidated; The objective of this study was to determine the metabolites that arise with the ingestion of clenbuterol-Clb and its possible derivatives that are stored mainly in the liver, pancreatic structure, adrenal gland, smooth and striated muscles, central and peripheral nervous system and genital organs.The fat content is dramatically reduced when clenbuterol is used as anabolic, understood as anabolic, when Clb is administered orally or intramuscularly above the therapeutic dose, between 5 and 10 times its concentration (0.08µg/body weight two times a day).For this study, 17 different metabolites were measured with the purpose of determining which