Why the study?
Does clenbuterol affect contractility and Ca2+ homeostasis in isolated rat ventricular myocytes compared to fenoterol and salbutamol?
Population
Isolated rat ventricular myocytes
Comparison
Clenbuterol (30 microM) vs Fenoterol and salbutamol
Design
Preclinical
Authors
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May caution clenbuterol in LVAD-supported HF; leaves open translation to human myocardium.
Does clenbuterol affect contractility and Ca2+ homeostasis in isolated rat ventricular myocytes compared to fenoterol and salbutamol?
Clenbuterol acutely depresses contractility in isolated rat ventricular myocytes via a Gi protein-dependent pathway, providing mechanistic insight into its effects in heart failure patients with LVADs.
Siedlecka et al. (2008) studied this question.
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