Why the study?
Does clenbuterol improve left ventricular function and cellular mechanics in a rat model of heart failure with mechanical unloading?
Population
Male Lewis rats with heart failure induced by left coronary artery ligation, undergoing heterotopic…
Comparison
Clenbuterol via osmotic minipumps for 7 days vs Saline via osmotic minipumps for 7 days
Design
Preclinical
Follow-up
7 days
Authors
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Should not yet change LVAD practice; hypothesis-generating for clenbuterol-enhanced recovery and requires clinical trials.
Does clenbuterol improve left ventricular function and cellular mechanics in a rat model of heart failure with mechanical unloading?
Clenbuterol improves left ventricular function and cellular mechanics in a rat model of heart failure with mechanical unloading, supporting its potential use to enhance myocardial recovery in patients with LVADs.
Soppa et al. (2008) studied this question.
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