Formulation of Guava Leaf Extract Gel Preparation (Psidium Guajava L.) as a Thrush Therapy

TThe guava leaf plant (Psidium guajava L.) is a plant that can be used as a traditional medicine for thrush therapy and anti-diarrhea. The chemical content of guava leaf extract which functions as an antibacterial is tannin. This research aims to determine the concentration of guava leaf extract which can be formulated in gel dosage form with physical evaluation that meets the requirements. Guava leaf extract was made using the maceration method using 96% ethanol as a solvent, then the extract was tested first to see its antibacterial activity against Staphylococcus aureus, Streptococcus mutans and Escherichia coli using the well method. The results of antibacterial testing showed that concentrations of 3% and 6% were the optimal concentrations to be used as a gel preparation for thrush therapy, this was indicated by the widest inhibitory diameter. FI guava leaf extract gel formula (3%) is the best formula which has the characteristics of a dark green color, a distinctive aroma of guava leaves, and is homogeneity. It also has pH of 6,005±0.023, viscosity of 270±30.472 dPas, spread ability of 5,035±0.071 mm.