June 19, 2024Frontiers in OncologyOpen Access

Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma

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Hepatocellular carcinoma prevalence exceeds 50% in hepatitis B cases, driven by the viral regulatory protein HBx altering host proto-oncogenes and tumor suppressor genes.
Review synthesis outlines how the pleiotropic HBx protein promotes cccDNA transcription and coordinates with transforming growth factor-β across distinct liver disease stages.
Understanding cooperative signaling between HBx and transforming growth factor-β highlights potential therapeutic targets, though clinical translation requires further validation.

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Implication

Review reveals dual roles of TGF-beta and HBx interactions in hepatocellular carcinoma, highlighting cooperative mechanisms in liver tumor progression.

Cite This Study

Yan et al. (2024) studied this question.

synapsesocial.com/papers/68e64178b6db6435875d2b54 https://doi.org/10.3389/fonc.2024.1407434

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Implication

Review reveals dual roles of TGF-beta and HBx interactions in hepatocellular carcinoma, highlighting cooperative mechanisms in liver tumor progression.

Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma

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Discussion

Implication

Cite This Study

Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma

Key Points

Discussion

Implication

Cite This Study

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