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Laboratory study reveals retrograde adenosine A2A receptor signaling promotes excitatory transmission and seizure activity, highlighting targets for controlling neuronal circuit excitability.
Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal circuit function is fine-tuned upon activity. While long-term changes in neurotransmitter release commonly rely on retrograde signaling, the mechanisms remain poorly understood. Here, we identified adenosine/A
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Nasrallah et al. (2024) studied this question.
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