June 19, 2024Open Access

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

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Hepatic miR-182-5p upregulation impairs glucose homeostasis and drives hepatic steatosis, linking metabolic dysfunction directly to suppressed LRP6 expression.
Validation across 85 human liver samples confirmed marked downregulation of LRP6, while seven days of viral overexpression induced elevated liver triglycerides.
MicroRNA microarray analysis of obese human biopsies and diet-induced mouse models was combined with a novel seed prediction tool to map lipid metabolism regulators.
Highlights miR-182-5p as a therapeutic target to curtail lipogenesis in type 2 diabetes—mouse model; further preclinical work needed to confirm clinical efficacy.

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Implication

Case-control analysis reveals elevated miR-182-5p impairs glucose homeostasis in obese individuals, suggesting a therapeutic target for hepatic steatosis.

Cite This Study

Krause et al. (2024) studied this question.

synapsesocial.com/papers/68e64198b6db6435875d3b1d https://doi.org/10.7554/elife.92075.2

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Implication

Case-control analysis reveals elevated miR-182-5p impairs glucose homeostasis in obese individuals, suggesting a therapeutic target for hepatic steatosis.

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

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Implication

Cite This Study

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

Key Points

Discussion

Implication

Cite This Study

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