June 17, 2024Pharmacogenetics and PharmacogenomicsOpen Access

Personalized approach to prediction and prevention of haloperidol-induced QT interval prolongation: brief review

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Authors

РНР. Ф. НасыроваSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute AKA. V. KidyaevaSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute VGV. V. GrechkinaSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute

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Implication

Literature review shows haloperidol-induced QT prolongation risk in psychiatric patients, highlighting the preventive utility of predictive pharmacogenetic testing.

Key Points

Haloperidol cardiotoxicity involves dose-dependent inhibition of cardiomyocyte potassium channels, which increases risks of QT interval prolongation and torsade de pointes.
Review of studies published between 02/01/2013 and 02/01/2024 across three databases shows decreased hepatic metabolism elevates haloperidol blood concentrations.
Highlights indicate predictive pharmacogenetic testing may guide haloperidol dosing, reducing potentially fatal cardiac complications in patients with mental disorders.

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Насырова et al. (2024) studied this question.

synapsesocial.com/papers/68e64668b6db6435875d74bf https://doi.org/10.37489/2588-0527-2024-1-20-30

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Implication

Literature review shows haloperidol-induced QT prolongation risk in psychiatric patients, highlighting the preventive utility of predictive pharmacogenetic testing.

Personalized approach to prediction and prevention of haloperidol-induced QT interval prolongation: brief review

Discussion

Member takes

Implication

Key Points

Cite This Study

Personalized approach to prediction and prevention of haloperidol-induced QT interval prolongation: brief review

Discussion

Member takes

Implication

Key Points

Cite This Study

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