Key result
Low-dose haloperidol administration did not significantly affect the QTc interval in critically ill patients after cardiac surgery (r = 0.144, p = 0.23).
Why the study?
It remains unclear whether low-dose haloperidol administration affects the QTc interval in critically ill patients following cardiac surgery.
Does low-dose haloperidol cause QTc prolongation in critically ill patients post cardiovascular surgery?
Population
68 critically ill patients with delirium after cardiac surgery in an ICU
Comparison
Electrocardiograms prior to vs within 24 h after haloperidol administration
Design
Retrospective cohort study
Follow-up
Within 24 h after haloperidol administration
Authors
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Supports low-dose haloperidol in post-cardiac surgery ICU patients; hypothesis-generating and requires prospective confirmation.
Cohort (n=68)
No
Does low-dose haloperidol cause QTc prolongation in critically ill patients post cardiovascular surgery?
Effect estimate: r = 0.144
p-value: p=0.23
Low-dose haloperidol appears safe and does not significantly prolong the QTc interval in critically ill patients post cardiovascular surgery.
Ibrahimi et al. (2020) conducted a cohort in Delirium in critically ill patients post cardiovascular surgery (n=68). Haloperidol vs. Pre-administration baseline was evaluated on QTc interval change (r = 0.144, p=0.23). Low-dose haloperidol administration did not significantly affect the QTc interval in critically ill patients after cardiac surgery (r = 0.144, p = 0.23).
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