Key result
Intravenous haloperidol is linked to QT prolongation and torsades de pointes in medically ill patients.
Why the study?
Intravenous haloperidol is commonly used for sedation in agitated, delirious ICU patients but its association with QT prolongation and torsades de pointes is not well characterized.
Does intravenous haloperidol cause torsades de pointes or Q-T prolongation in medically ill patients?
Comparison
Intravenous haloperidol exposure
Design
Case report
Authors
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Cautions against unmonitored IV haloperidol in medically ill patients; leaves open the true incidence and risk factors.
Case Report (n=3)
Does intravenous haloperidol cause torsades de pointes or Q-T prolongation in medically ill patients?
Intravenous haloperidol can cause Q-T prolongation and torsades de pointes, suggesting the need for cardiac monitoring, especially in patients with risk factors like dilated cardiomyopathy or alcohol abuse history.
Metzger et al. (1993) conducted a case report in Agitation and delirium in medically ill patients (n=3). Intravenous haloperidol was evaluated on Torsades de pointes arrhythmia or lengthening of the Q-T interval. Intravenous haloperidol treatment in three medically ill patients was associated with the development of torsades de pointes arrhythmia or lengthening of the Q-T interval.
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