June 14, 2024Diabetes

1546-P: Autonomic Intrapancreatic Neurons Alterations in Type 1 Diabetes

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Authors

SES. G. EwingUniversity of California, San Francisco SHSydney HaseldenSeminole State College of Florida MNMalavika A. NairSeminole State College of Florida

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Implication

Postmortem analysis reveals reduced neuronal marker expression in intrapancreatic ganglia from donors with type 1 diabetes, indicating altered parasympathetic regulation.

Key Points

Donors with type 1 diabetes exhibit a marked reduction in neuronal HuC/D marker expression in intrapancreatic ganglia, with smaller neuron sizes noted in the smallest ganglia.
Analysis of 83 ganglia from 15 non-diabetic and 9 type 1 diabetes organ donors using multiplex immunofluorescence revealed significantly reduced HuC/D area without synapse loss.
These findings highlight autonomic neurostructural alterations during diabetes, though synapse density and IBA1 macrophage markers remain unaffected in human donor tissues.

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Ewing et al. (2024) studied this question.

synapsesocial.com/papers/68e64c55b6db6435875dd697 https://doi.org/10.2337/db24-1546-p

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Implication

Postmortem analysis reveals reduced neuronal marker expression in intrapancreatic ganglia from donors with type 1 diabetes, indicating altered parasympathetic regulation.

1546-P: Autonomic Intrapancreatic Neurons Alterations in Type 1 Diabetes

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Key Points

Cite This Study

1546-P: Autonomic Intrapancreatic Neurons Alterations in Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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