June 1, 2024Cell ReportsOpen Access

Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes

View Full Paper

Ask AI

Bookmark

Authors

DDDenise M. DrotarUniversity of Florida AMAna Karen Mojica-AvilaHelmholtz Zentrum München DBDrew T. BlossUniversity of Florida

Discussion

Member takes

Implication

Tissue analysis demonstrates uniform reduction of islet function across pancreas regions in type 1 diabetes, suggesting consistent regional pathology.

Key Points

Insulin secretion and beta-cell volume decline uniformly across all pancreatic regions in type 1 diabetes, while exocrine enzyme output remains preserved.
In single islet autoantibody donors (n = 7), beta-cell volume is reduced despite normal insulin secretion, leading to elevated volume-adjusted insulin output.
Tissue morphometry and secretion assays across 27 donors show minimal regional variation, highlighting increased metabolic demand in early autoantibody stages.

Cite This Study

Drotar et al. (2024) studied this question.

synapsesocial.com/papers/68e669b0b6db6435875f5bab https://doi.org/10.1016/j.celrep.2024.114346

View Full Paper

Ask AI

Bookmark

Implication

Tissue analysis demonstrates uniform reduction of islet function across pancreas regions in type 1 diabetes, suggesting consistent regional pathology.

Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider